Lehrstuhl für Biochemie und Pathobiochemie
Leitung: Prof. Dr. Michael Wegner
2013
- Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB. (2013)
- Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.
- Brain, 136, 549-563
- Wegner M. (2013)
- Mighty bugs: leprosy bacteria turn schwann cells into stem cells.
- Cell, 152, 15-16
- Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S. (2013)
- The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
- Development, 140, 740-750
- Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, Watanabe S. (2013)
- Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development.
- FEBS Lett, 587, 358-63
nach oben
2012
- Weider, M., Küspert, M., Bischof, M., Vogl, M.R., Hornig, J., Loy, K., Kosian, T., Müller, J., Hillgärtner, S., Tamm, E.R., Metzger, D., Wegner, M. (2012)
- Chromatin remodelling factor Brg1 is required for Schwann cell differentiation and myelination.
- Dev. Cell, 23, 193-201
- Shakhova, O., Zingg, D., Schaefer, S.M., Hari, L., Civenni, G., Blunschi, J., Claudinot, S., Okoniewski, M., Beermann, F., Mihic-Probst, D., Moch, H., Wegner, M., Dummer, R., Barrandon, Y., Cinelli, P., Sommer, L. (2012)
- Sox10 promotes the formation and maintenance of giant congenital nevus and melanoma.
- Nat. Cell. Biol., 14, 882-890
- Küspert, M., Weider, M., Müller, J., Hermans-Borgmeyer, I., Meijer, D., Wegner, M. (2012)
- Desert Hedgehog links transcription factor Sox10 to perineurial development.
- J. Neurosci, 32, 5472–5480
- Yusuf, D., Butland, S.L., Swanson, M.I., Bolotin, E., Ticoll, A., Cheung, W.A., Zhang, X.Y., Dickman, C.T., Fulton, D.L., Lim, J.S., Schnabl, J.M., Ramos, O.H., Vasseur-Cognet, M., de Leeuw, C.N., Simpson, E.M., Ryffel, G.U., Lam, E.W., Kist, R., Wilson, M.S., Marco-Ferreres, R., Brosens, J.J., Beccari, L.L., Bovolenta, P., Benayoun, B.A., Monteiro, L.J., Schwenen, H.D., Grontved, L., Wederell, E., Mandrup, S., Veitia, R.A., Chakravarthy, H., Hoodless, P.A., Mancarelli, M., Torbett, B.E., Banham, A.H., Reddy, S.P., Cullum, R.L., Liedtke, M., Tschan, M.P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P.J., Eijkelenboom, A., Brown, P.J., Laperriere, D., Leprince, D., de Cristofaro, T., Prince, K.L., Putker, M., Del Peso, L., Camenisch, G., Wenger, R.H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S.J., Van Rechem, C., Boulay, G., Olechnowicz, S.W., Breslin, M.B., Lan, M.S., Nanan, K.K., Wegner, M., Hou, J., Mullen, R.D., Colvin, S.C., Noy, P.J., Webb, C.F., Witek, M.E., Ferrell, S., Daniel, J.M., Park, J., Waldman, S.A., Peet, D.J., Taggart, M., Jayaraman, P.S., Karrich, J.J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R.M., Woodcroft, M.W., Hough, M.R., Chen, E., Europe-Finner, N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., Lebrun, D.P., Biswal, S., Harvey, C.J., Debruyne, J.P., Hogenesch, J.B., Hevner, R.F., Heligon C., Luo, X. M., Blank, M. C., Millen, K. J., Sharlin, D. S., Forrest, D., Dahlman-Wright, K., Zhao, C. Mishima, Y. Sinha, S., Chakrabarti, R., Portales-Casamar, E., Sladek, F. M., Bradley, P. H., Wasserman, W. W. (2012)
- The Transcription Factor Encyclopedia.
- Genome Biology, 13:R24
- Mu, L., Berti, L., Masserdotti, G., Covic, M., Michaelidis, T., Doberauer, K., Merz, K., Rehfeld, F., Haslinger, A., Wegner, M., Sock, E., Lefebvre, V., Couillard-Despres, S., Aigner, L., Berninger, B., Lie, D.C. (2012)
- SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.
- J. Neurosci, 32, 3067-3080
- Fröb, F., Bremer, M., Finzsch, M., Kichko, T., Reeh, P., Tamm, E.R., Charnay, P., Wegner, M. (2012)
- Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10.
- Glia, 60, 806-819
- Wahlbuhl M, Reiprich S, Vogl MR, Bösl MR, Wegner M. (2012)
- Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene.
- Nucleic Acids Res., 40:88-101
nach oben
2011
- Wegner M. (2011)
- SOX after SOX: SOXession regulates neurogenesis.
- Genes Dev., 25:2423-2428
- John, N., Cinelli, P., Wegner, M., Sommer, L. (2011)
- Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells.
- Stem Cells, 29:689-699
- Bremer, M., Fröb, F., Kichko, T., Reeh, P., Tamm, E.R., Suter, U., Wegner, M. (2011)
- Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve.
- Glia, 59:1022-1032
- Küspert, M., Hammer, A., Bösl, M.R., Wegner, M. (2011)
- Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer.
- Nucleic Acids Res., 39:1280-1293
- Lin, L., Lee, V.M., Wang, Y., Lin, J.S., Sock, E., Wegner, M., Lei, L. (2011)
- Sox11 regulates survival and axonal growth of embryonic sensory neurons.
- Dev. Dyn., 240:52-64
- Gallenberger, M., Meinel, D., Kroeber, M., Wegner, M., Milkereit, P., Bösl, M.R., Tamm, E.R. (2011)
- Lack of Wdr36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.
- Hum. Mol. Genet., 20:422-435
- Reginensi, A., Clarkson, M., Neirijnck, Y., Lu, B., Ohyama, T., Groves, A.K., Sock, E., Wegner, M., Costantini, F., Chaboissier, M.C., Schedl, A. (2011)
- SOX9 controls epithelial branching by activating RET effector genes during kidney development.
- Hum. Mol. Genet., 20:1143-1153
nach oben
2010
- Wallace, A., Schmidt, C., Schachner, M., Wegner, M., Anderson, R. (2010)
- L1cam acts as a modifier gene during enteric nervous system development.
- Neurobiol. Dis., , 40, 622-633
- Thein, D.C., Thalhammer, J.M., Hartwig, A.C., Crenshaw III, E.B., Lefebvre, V., Wegner, M., Sock, E. (2010)
- The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
- J. Neurochem., , 115, 131-141
- Breuskin, I., Bodson, M., Thelen, N., Thiry, M., Borgs, L., Nguyen, L., Stolt, C., Wegner, M., Lefebvre, P.P., Malgrange, B. (2010)
- Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.
- J. Neurochem., , 114, 1827-1839
- Finzsch, M., Schreiner, S., Kichko, T., Reeh, R., Tamm, E.R., Bösl, M.R., Meijer, D., Wegner, M. (2010)
- Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.
- J. Cell. Biol. , 189, 701-712
- Cossais, F., Wahlbuhl, M., Kriesch, J.,Wegner, M. (2010)
- SOX10 structure function analysis in the chicken reveals important insights into its role in human neurocristopathies.
- Hum. Mol. Genet. , 19, 2409-2420
- Bhattaram, P., Penzo-Méndez, A., Sock, E., Colmenares, C., Kaneko, K.J., Vassilev, A., DePamphilis, M.L., Wegner, M., Lefebvre, V. (2010)
- Organogenesis relies on Sox4, Sox11, and Sox12 for survival of neural and mesenchymal progenitor cells.
- Nat. Commun. , 1, 9
- Staffler, A., Hammel, M., Wahlbuhl, M., Bidlingmaier, C., Flemmer, A.W., Pagel, P., Nicolai, T., Wegner, M., Holzinger, A. (2010)
- Heterozygous SOX9 mutations allowing for residual DNA-binding and transcriptional activation lead to the acampomelic variant of Campomelic Dysplasia.
- Hum. Mut. , 31, E1436-1444
- Cossais, F., Sock, E., Hornig, J., Schreiner, S., Kellerer, S., Bösl, M.R., Russell, S., Wegner, M. (2010)
- Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.
- Dev. Biol. , 341, 267-281
- Kanaykina, N., Abelson, K., King, D., Liakhovitskaia, A., Schreiner, S., Wegner, M., Kozlova, E.N. (2010)
- In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behaviour.
- Ups. J. Med. Sci. , 115, 56-64
- Potzner, M.R., Tsarovina, K., Binder, E., Penzo-Méndez, A., Lefebvre, V., Rohrer, H., Wegner, M., Sock, E. (2010)
- Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.
- Development , 137, 775-784
- Park, J., Zhang, J.J.R., Moro, A., Kushida, M., Wegner, M., Kim, P.C.W. (2010)
- Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage.
- Dev. Dyn. , 239, 514-526
- Guth, S.I.E., Bösl, M.R., Sock, E., Wegner, M. (2010)
- Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene.
- Int. J. Biochem. Cell Biol. , 42, 465-471
- Stolt, C.C., Wegner, M. (2010)
- SoxE function in vertebrate nervous system development.
- Int. J. Biochem. Cell Biol. , 42, 437-440
- Wegner, M. (2010)
- All purpose SOX: The many roles of Sox proteins in gene expression.
- Int. J. Biochem. Cell Biol. , 42, 381-390
- Reiprich, S., Kriesch, J, Schreiner, S. Wegner, M. (2010)
- Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells.
- J. Neurochem. , 112, 744-754
nach oben
2009
- Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis,V., Fishell, G. (2009)
- The cell-intrinsic requirement of Sox6 for cortical interneuron development.
- Neuron , 63, 466-481
- Wolf, M., Lommes, P., Sock, E., Reiprich, S., Friedrich, R.P., Kriesch, J., Stolt, C.C., Bermingham, J.R., Wegner, M. (2009)
- Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.
- Dev. Biol. , 332, 418-428
- Aldskogius, H., Berens, C., Kanaykina, N., Liakhovitskaia, A., Medvinsky, A., Sandelin, M., Schreiner, S., Wegner, M., Hjerling-Leffler, J., Kozlova, E.N. (2009)
- Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation.
- Stem Cells , 27, 1592-1603
- Guth, S.I.E., Schmidt, K., Hess, A., Wegner M. (2009)
- Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor.
- J. Lipid Res. , 50, 1269-1280
- Barrionuevo, F., Georg, I., Scherthan, H., Lécureuil, C., Guillou, F., Wegner, M., Scherer, G. (2009)
- Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8.
- Dev. Biol. , 327, 301-312
nach oben
2008
- Reiprich, S., Stolt, C.C., Schreiner, S., Parlato, R., Wegner, M. (2008)
- SoxE proteins are differentially required in mouse adrenal gland development.
- Mol. Biol. Cell., 19,1575-1586
- Stolt, C.C., Lommes, P., Hillgärtner, S., Wegner, M. (2008)
- The transcription factor Sox5 modulates Sox10 function during melanocyte development.
- Nucleic Acids Res. , 36, 5427-5440
- Hoser, M., Potzner, M.R., Koch, J.M.C., Bösl, M.R., Wegner, M., Sock, E. (2008)
- Sox12 deletion in the mouse reveals non-reciprocal redundancy with the related Sox4 and Sox11 transcription factors.
- Mol. Cell. Biol. , 28, 4675-4687
- Guth, S.I.E., Wegner, M. (2008)
- Having it both ways: Sox protein function between conservation and innovation.
- Cell. Mol. Life Sci. , 65, 3000-3018
- Hoff, S., Zeller, F., Hann von Weyhern, C.W., Wegner, M., Schemann, M., Michel, K., Rühl, A. (2008)
- Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
- J. Comp. Neurol. , 509, 356-371
- Wurm, A., Sock, E., Fuchshofer, R., Wegner, M., Tamm, E.R. (2008)
- Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11.
- Exp. Eye Res. , 86, 895-907
- Aquino, J.B., Marmigere, F., Lallemend, F., Lundgren, T.K., Villar, M.J., Wegner, M., Ernfors, P. (2008)
- Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.
- Gene Expr. Patterns, 8, 217-226
- Müller, S.M., Stolt, C.C., Terszowski, G., Blum, C., Amagai, T., Kessaris, N., Iannarelli, P., Richardson, W.D., Wegner, M., Rodewald, H.R. (2008)
- Neural crest origin of perivascular mesenchyme in the adult thymus.
- J. Immunol. , 180, 5344-5351
- Wang, H., Leav, I., Ibaragi, S., Wegner, M., Hu, G.F., Lu, M., Balk, S., Yuan, X. (2008)
- SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion.
- Cancer Res., 68, 1625-1630
- Wegner, M. (2008)
- A matter of identity: transcriptional control in oligodendro-cytes.
- J. Mol. Neurosci., 35, 3-12
- Finzsch, M., Stolt, C.C., Lommes, P., Wegner, M. (2008)
- Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.
- Development, 135, 637-646
nach oben
2007
- Inoue, K., Ohyama, T., Sakuragi, Y., Li-Hua, Y., Yamamoto, R., Yu, L.-H., Goto, Y-i., Wegner, M., Lupski, J.R. (2007)
- Translation of SOX10 3' untranslated region causes a complex severe neurocristopathy by generation of a deleterious functional domain.
- Hum. Mol. Genet., 16, 3037-3046
- Werner, T., Hammer, A., Wahlbuhl, M., Bösl, M.R., Wegner, M. (2007)
- Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis.
- Nucleic Acids Res., 35, 6526-6538
- Schreiner, S., Cossais, F., Fischer, K., Scholz, S., Bösl, M.R., Holtmann, B., Sendtner, M., Wegner, M. (2007)
- Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.
- Development, 134, 3271-3281
- Schlierf, B., Friedrich, R.P., Felsberg, J., Reifenberger, G., Wegner, M. (2007)
- Expression of SoxE and SoxD genes in human gliomas.
- Neuropathol. Appl. Neurobiol., 33, 621-630
- Potzner, M.R., Griffel, C., Lütjen-Drecoll, E., Bösl, M.R., Wegner, M., Sock, E. (2007)
- Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.
- Mol. Cell. Biol., 27, 5316-5326
- Hoser, M., Baader, S.L., Bösl, M.R., Ihmer, A., Wegner, M., Sock, E. (2007)
- Prolonged glial expression of Sox4 in the central nervous system leads to architectural cerebellar defects and ataxia.
- J. Neurosci., 27, 5495-5505
- Liu, Z., Hu, X., Cai, J., Liu, B., Peng, X., Wegner, M., Qiu, M. (2007)
- Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms.
- Dev. Biol., 302, 683-693
nach oben
2006
- Stolt, C.C., Schlierf, A., Lommes, P., Hillgärtner, S., Werner, T., Kosian, T., Sock, E., Kessaris, N., Richardson, W.D., Lefebvre, V., Wegner, M. (2006)
- SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.
- Dev. Cell, 11, 697-709
- Schlierf, B., Werner, T., Glaser, G., Wegner, M. (2006)
- Expression of Connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor.
- J. Mol. Biol., 361, 11-21
- Kellerer, S., Schreiner, S., Stolt, C.C., Scholz, S., Bösl, M.R., Wegner, M. (2006)
- Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.
- Development, 133, 2875-2886
- Ito, Y., Wiese, S., Chittka, A., Rossoll, W., Bömmel, H., Watabe, K., Wegner, M., Sendtner, M. (2006)
- Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells.
- Proc. Natl. Acad. Sci. USA, 103, 7871-7876
- Wißmüller, S., Kosian, T., Wolf, M., Wegner, M. (2006)
- The High-mobility-group domain of Sox proteins interacts with the DNA-binding domains of many transcription factors.
- Nucleic Acids Res., 34, 1735-1744
- Marmigère, F., Montelius, A., Wegner, M., Groner, Y., Reichardt, L.F., Ernfors, P. (2006)
- The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.
- Nat. Neurosci., 9, 180-187
- Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., Richardson, W.D. (2006)
- Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an early embryonic lineage.
- Nat. Neurosci., 9, 173-179
- Bannykh, S.I., Stolt, C.C., Kim, J., Perry, A. and Wegner, M. (2006)
- Oligo-dendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.
- J. Neurooncol., 76, 115-127
nach oben
2005
- Baranek, C., Sock, E. and Wegner, M. (2005)
- The POU protein Oct-6 is a nucleocytoplasmic shuttling protein.
- Nucleic Acids Res., 33, 6277-6286
- Schlierf, B., Lang, S., Kosian, T. and Wegner, M. (2005)
- The high-mobility group transcription factor Sox10 interacts with the N-myc interacting protein Nmi.
- J. Mol. Biol., 353, 1033-1042
- Thomee, C., Schubert, S.W., Parma, J., Le, P.Q., Hashemolhosseini, S., Wegner, M. and Abramowicz, M.J. (2005)
- GCMB mutation in familial isolated hypo-parathyroidism with residual secretion of parathyroid hormone.
- J. Clin. Endocrinol. Metab., 90, 2487-2492
- Stolt, C.C., Schmitt, S., Lommes, P., Sock, E. and Wegner, M. (2005)
- Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.
- Dev. Biol., 281, 309-317
- Schmidt, K., Schinke, T., Haberland, M., Priemel, M., Schilling, A.F., Mueldner, C., Rueger, J.M., Sock, E., Wegner, M., and Amling, M. (2005)
- The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
- J. Cell. Biol., 168, 899-910
- Friedrich, R., Schlierf, B., Tamm, E.R., Bösl M.R. and Wegner, M. (2005)
- The class III POU domain protein Brn-1 can fully replace the related Oct-6 during Schwann cell development and myelination.
- Mol. Cell. Biol., 25, 1821-1829
- Maka, M., Stolt, C.C. and Wegner, M. (2005)
- Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect.
- Dev. Biol., 277, 155-169
- Wegner, M. and Stolt, C.C. (2005)
- From stem cells to neurons and glia: a soxist's view of neural development.
- Trends Neurosci., 28, 583-588
- Wegner, M. (2005)
- Secrets to a healthy Sox life: Lessons for melanocytes.
- Pigment Cell Res., 18, 74-85
nach oben
2004
- Schubert, S.W., Kardash, E., Khan, M.A., Cheusova, T., Kilian, K., Wegner, M. and Hashemolhosseini, S. (2004)
- Interaction, Cooperative Promoter Modulation and Renal Colocalisation of GCMa and Pitx2.
- J. Biol. Chem., 279, 50358-50365
- Ludwig, A., Schlierf, B., Schardt, A., Nave, K.A. and Wegner, M. (2004)
- A Sox10 rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.
- Genesis, 40, 171-175
- Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R. and Wegner, M. (2004)
- Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling.
- Mol. Cell. Biol., 24, 6635-6644
- Inoue, K., Khajavi, M., Ohyama, T., Hirabayashi, S.-i., Wilson, J., Reggin, J.D., Mancias, P., Butler, I.J., Wilkinson, M.F., Wegner, M. and Lupski, J.R. (2004)
- Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations.
- Nature Genetics, 36, 361-369
- Stolt, C.C., Lommes, P., Friedrich, R.P. and Wegner, M. (2004)
- Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy.
- Development, 131, 2349-2358
- Chaboissier, M.-C., Kobayashi, A., Vidal, V.I.P., Lützkendorf, S., van de Kant, H.J.G., Wegner, M., de Rooij, D.G., Behringer, R.R., and Schedl, A. (2004)
- Functional analysis of Sox8 and Sox9 during sex determination in the mouse.
- Development, 131, 1891-1901
- Hashemolhosseini, S., Schmidt, K., Kilian, K., Rodriguez, E. and Wegner, M. (2004)
- Conservation and variation of structure and function in a newly identified GCM homolog from chicken
- J. Mol. Biol., 336, 441-451
- Ludwig, A., Rehberg, S., and Wegner, M. (2004)
- Melanocyte-Specific Expression Of Dopachrome Tautomerase Is Dependent On Synergistic Gene Activation By The Sox10 And Mitf Transcription Factors.
- FEBS Lett., 556, 236-244
- Hashemolhosseini, S. and Wegner, M. (2004)
- Impacts of a new transcription factor familiy: Mamalian GCM proteins in health and disease.
- J. Cell. Biol., 166, 765-768
nach oben
2003
- Hashemolhosseini, S., Kilian, K., Kardash, E., Lischka, P., Stamminger, T. and Wegner, M. (2003)
- Structural requirements for nuclear localization of GCMa/Gcm-1.
- FEBS Lett., 553, 315-320
- Huber, W.E., Price, R., Widlund, H.R., Du, J., Davis, I.J., Wegner, M. and Fisher, D.E. (2003)
- A tissue restricted cAMP transcriptional response: SOX10 modulates MSH-triggered expression of MITF in melanocytes.
- J Biol. Chem., 278, 45224-45230
- Schmidt, K., Glaser, G., Wernig, A., Wegner, M. and Rosorius, O. (2003)
- Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis.
- J. Biol. Chem., 278, 29769-29775
- Download (411 KB)
- Lioubinski, O., Müller, M., Wegner, M. and Sander, M. (2003)
- Expression of Sox transcription factors in the developing mouse pancreas.
- Dev. Dyn., 227, 402-408
- Stolt, C.C., Lommes, P., Sock, E., Chaboissier, M.-C., Schedl, A. and Wegner, M. (2003)
- The Sox9 transcription factor determines glial fate choice in the developing spinal cord.
- Genes Dev., 17,1677-1689
- Download (1334 KB)
- Sock, E., Pagon, R.A., Keymolen, K., Lissens, W., Wegner, M. and Scherer, G. (2003)
- Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia.
- Hum. Mol. Genet., 12, 1439-1447
- Download (972 KB)
- Cohen, S.X., Moulin, M., Hashemolhosseini, S., Kilian, K., Wegner, M. und Müller, C.W. (2003)
- Structure of the GCM domain-DNA complex, a DNA-binding domain with a novel fold and mode of target site ecognition.
- EMBO, 22, No. 8 pp. 1835-1845
- Download (591 KB)
nach oben
2002
- Schlierf, B., Ludwig, A., Klenovsek, K. and Wegner, M. (2002)
- Cooperative binding of Sox10 to DNA, requirements and consequences.
- Nucleic Acids Res., 30, 5509-5516.
- Download (198 KB)
- Cohen, S.X., Moulin, M., Schilling, O. , Meyer-Klaucke, W., Schreiber, J., Wegner, M. and Müller, C.W. (2002)
- The GCM-domain is a Zn-coordinating DNA-binding domain
- FEBS Lett., 528, 95-100
- Download (430 KB)
- Hashemolhosseini, S., Hadjihannas, M., Stolt, C.C., Haas, C.S., Amann, K. and Wegner, M. (2002)
- Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.
- Mech. Dev., 118, 175-178
- Download (457 KB)
- Rehberg, S., Lischka, P., Glaser, G., Stamminger, S., Wegner, M. and Rosorius, O. (2002)
- Sox10 is an active nucleocytoplasmic shuttle protein and shuttling is crucial for Sox10-mediated transactivation.
- Mol. Cell. Biol., 22, 5826-5834
- Download (534 KB)
- Stolt, C.C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U. and Wegner, M. (2002)
- Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
- Genes Dev., 16, 165-170
- Download (372 KB)
nach oben
2001
- Wegner, M. und Riethmacher, D. (2001)
- Chronicles of a switch hunt, gcm genes in development.
- Trends Genet., 17, 286-290
- Download (408 KB)
- Wegner, M. (2001)
- Expression of transcription factors during oligodendroglial development.
- Micros. Res. Tech., 52, 746-752
- Download (140 KB)
- Sonnenberg-Riethmacher, E., Miehe, M., Stolt, C.C., Goerich, D.E., Wegner M. and Riethmacher, D. (2001)
- Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10.
- Mech. Dev., 109, 253-265
- Paratore, C., Goerich, D.E., Suter, U., Wegner, M. and Sommer, L. (2001)
- Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox 10 and extrinsic combinatorial signaling.
- Development, 128, 3949-3961
- Download (690 KB)
- Sock, E., Schmidt, K., Hermanns-Borgmeyer, I., Bösl, M.R. and Wegner, M. (2001)
- Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8.
- Mol. Cell. Biol., 21, 6951-6959
- Download (1060 KB)
- Britsch, S., Goerich, D.E., Riethmacher, D., Peirano, R.I., Rossner, M., Nave, K.-A., Birchmeier, C. and Wegner M. (2001)
- The transcription factor Sox10is a key regulator of peripheral glial development.
- Genes Dev., 15, 66-78
- Download (1290 KB)
nach oben
2000
- Wegner, M. (2000)
- Transcriptional control in glia, flavors and spices.
- Glia, 31, 1-14
- Download (135 KB)
- Wegner, M. (2000)
- Transcriptional control in glia, the basic recipe.
- Glia, 29, 118-123
- Download (108 KB)
- Bondurand, N., Pingault, V., Goerich, D.E., Lemort, N., Sock, E., Le Caignec, C., Wegner, M. and Goossens, M. (2000)
- Interaction between SOX10, PAX3 and MITF, three genes implicated in Waardenburg syndrome.
- Hum. Mol. Genet., 9, 1907-1917
- Download (509 KB)
- Peirano, R.I. and Wegner, M. (2000)
- The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences.
- Nucleic Acids Res., 28, 3047-3055
- Download (566 KB)
- Peirano, R.I., Goerich, D.E., Riethmacher, D. and Wegner, M. (2000)
- Protein zero expression is regulated by the glial transcription factor Sox10.
- Mol. Cell. Biol., 20, 3198-3209
- Download (2912 KB)
nach oben
1999
- Wegner, M. (1999)
- From head to toes, the multiple facets of Sox proteins.
- Nucleic Acids Res., 27, 1409-1420
- Download (245 KB)
- Schneider, C., Wicht, H., Enderich, J., Wegner, M. and Rohrer, H. (1999)
- Bone morphogenetic proteins are required for the development of sympathetic neurons.
- Neuron, 24, 861-870
- Bondurand, N., Kuhlbrodt, K., Pingault, V., Enderich, J., Sajus, M., Tommerup, N., Warburg, M., Hennekam, R.C.M., Read, A.P., Wegner, M. und Goossens, M. (1999)
- A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome, SOX10 dysfunction causes different neurocristopathies.
- Hum. Mol. Genet., 8, 1785-1789
nach oben
1998
- Pingault, V., Bondurand, N., Kuhlbrodt, K., Goerich, D.E., Prèhu, M.O., Puliti, A., Herbarth, B., Hermans-Borgmeyer, I., Legius, E., Matthijs, G., Amiel, J., Lyonnet, S., Ceccherini, I., Romeo, G., Smith, J.C., Read, A.P., Wegner, M. and Goossens, M. (1998)
- SOX10 mutations in patients with Waardenburg-Hirschsprung disease.
- Nature Genetics, 18, 171-173
- Bondurand, N., Kobetz, A., Pingault, V., Lemort, N., Encha-Razavi, F., Couly, G., Goerich, D., Wegner, M., Abitbol, M. und Goossens M. (1998)
- Expression of the SOX10 gene during human development.
- FEBS Lett., 432, 168-172
- Kuhlbrodt, K., Schmidt, C., Sock, E., Pingault, V., Bondurand, N., Goossens, M. and Wegner, M. (1998)
- Functional analysis of Sox10 mutations in human Waardenburg-Hirchsprung patients.
- J. Biol. Chem., 273, 23033-23038
- Kuhlbrodt, K., Herbarth, B., Sock, E., Enderich, J., Hermans-Borgmeyer, I. and Wegner, M. (1998)
- Cooperativity between POU proteins and Sox proteins in glial cells.
- J. Biol. Chem., 273, 16050-16057
- Herbarth, B. Pingault, V., Bondurand, N., Kuhlbrodt, K., Hermans-Borgmeyer, I., Puliti, A., Lemort, N., Goossens, M. and Wegner, M. (1998)
- Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease.
- Proc. Natl. Acad. Sci. USA., 95, 5161-5165
- Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I. and Wegner, M. (1998)
- Sox10, a novel transcriptional modulator in glial cells.
- J. Neurosci., 18, 237-250
